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CBD Study- CBD for Depression, Anxiety and more....

Discussion in 'CBD Oil' started by Storm Crow, Jan 11, 2021.

  1. The link will take you to the full study.

    Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders. (Spain) (full – 2020) Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

    The potential therapeutic use of some Cannabis sativa plant compounds has been attracting great interest, especially for managing neuropsychiatric disorders due to the relative lack of efficacy of the current treatments. Numerous studies have been carried out using the main phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD displays an interesting pharmacological profile without the potential for becoming a drug of abuse, unlike THC. In this review, we focused on the anxiolytic, antidepressant, and antipsychotic effects of CBD found in animal and human studies. In rodents, results suggest that the effects of CBD depend on the dose, the strain, the administration time course (acute vs. chronic), and the route of administration. In addition, certain key targets have been related with these CBD pharmacological actions, including cannabinoid receptors (CB1r and CB2r), 5-HT1A receptor and neurogenesis factors. Preliminary clinical trials also support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant, and more importantly, a positive risk-benefit profile. These promising results support the development of large-scale studies to further evaluate CBD as a potential new drug for the treatment of these psychiatric disorders.


    New words -

    phytocannabinoids- cannabinoids that come from plants, like THC and CBD

    anxiolytic - preventing or stopping anxiety

    CB1r - Cannabinoid receptor type 1- these are the ones that get you high

    CB2r - cannabinoid receptor type 2- these are involved with controlling inflammation

    neurogenesis - the formation of new neurons (brain cells)

    When they mention strains, they are talking about the animals in the study, not the strain of cannabis. Only a few scientists have figured out that the strain of cannabis matters, too! :coolalt:

    Since a lot of folks are having problems with depression and anxiety, I thought I should mention Omega 3. It not only helps your mood, but it also helps you get high! Seems that your body can't properly make those high-creating CB1 receptors without a little Omega 3! They are left "uncoupled" from their effector G proteins (it's like a radio with a loose wire - everything is there, but no "music" happens). Because most cooking oils are high in Omega 6 and low in Omega 3, it is likely you are Omega 3 deficient! :eek2:

    “Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.” Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions - PubMed

    (n-3 = Omega 3)
    “In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins.”......"Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets."

    And a little more about those "behavioral alterations" that a lack of Omega 3 causes-

    How Omega-3 Fish Oil Affects Your Brain and Mental Health
    How Omega-3 Fish Oil Affects Your Brain and Mental Health

    Granny :wave:

     
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  2. Great information! Thanks Granny!:thumbsup:
     
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  3. According to my observation The human body has many different receptors. Receptors are protein-based chemical structures that are attached to your cells. They receive signals from different stimuli.
    which results in CBD to react in depressed state of minds.
     
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  4. we have predicted about 300 cannabinoid receptors while only researching two so far and elucidating to a third cb receptor ... because the cb receptors transport lipids outwardly a numerous amount of efferent shaped and structured lipids can do so .
     
  5. Cool story bro, Reported again for trying to scam people/sales.
     

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