In this study, they gave cats some pretty hefty doses of cannabinoids (30.5 mg/kg CBD (CBD oil), 41.5 mg/kg THC (THC oil) or 13.0:8.4 mg/kg CBD:THC (CBD/THC oil)) with only mild adverse events that needed no medical attention. The link leads to the full study. Safety and tolerability of escalating cannabinoid doses in healthy cats. (Canada) (full – 2021) SAGE Journals: Your gateway to world-class research journals Abstract Objectives The aim of this study was to determine the safety and tolerability of escalating doses of orally delivered cannabis oils predominant in cannabidiol (CBD), tetrahydrocannabinol (THC), or both CBD and THC in healthy cats. Methods In this placebo-controlled, blinded study, 20 healthy adult cats were randomized to one of five treatment groups (n = 4 per group): two placebo groups (sunflower oil [SF] or medium-chain triglyceride oil [MCT]), or three plant-derived cannabinoid oil groups (CBD in MCT, THC in MCT or CBD/THC [1.5:1] in SF). Up to 11 escalating doses of each formulation were delivered orally via syringe to fasted subjects, with at least 3 days separating doses. Safety and tolerability were determined from clinical observations, complete blood counts (CBCs) and clinical chemistry. Plasma cannabinoids (CBD, THC) and metabolites (7-COOH-CBD, 11-OH-THC) were assessed. Results Titration to maximum doses of 30.5 mg/kg CBD (CBD oil), 41.5 mg/kg THC (THC oil) or 13.0:8.4 mg/kg CBD:THC (CBD/THC oil) was safely achieved in all subjects. All observed adverse events (AEs) were mild, transient and resolved without medical intervention. Gastrointestinal AEs were more common with formulations containing MCT. Constitutional (lethargy, hypothermia), neurologic (ataxia) and ocular (protrusion membrana nictitans) AEs were more common with oils containing THC (CBD/THC and THC oils). There were no clinically significant changes in CBC or clinical chemistry across treatment groups. Higher plasma levels of the cannabinoids and their metabolites following administration of the CBD/THC combination product are suggestive of a pharmacokinetic interaction. Conclusions and relevance This is the first feline study to explore the safety and tolerability of CBD and THC, alone and in combination, in a controlled research setting. These findings will inform veterinarians of the safety profile of cannabinoids, particularly when considering the potential therapeutic use of CBD in cats or recognizing clinical signs associated with accidental exposure to THC-containing products. At 41.5 mg of THC per every 2.2 pounds of cat (41.5 mg/kg THC), those poor THC cats were quite stoned! If my math is right*, for a 10 pound cat, the maximum dose given was over 185 mg! MCT seems to give cats the "runs". After their stonedness and any tummy troubles wore off, the cats were fine. However, I truly doubt that their THC trip was pleasant. The CBD cats had a far better time of it. Minor points- The safety of the natural cannabinoids (even at insanely high doses) is once again verified, this time in cats. Also that mixing some CBD with THC may get more THC into the blood. New words- Ataxia- lack of muscle coordination during movements like walking hypothermia- sub-normal body temperature membrana nictitans - an animal's '3rd eyelid", its protrusion can indicate illness * (10 lb = 4.5 kg x 41.5 mg/kg = 186.7 mg) Granny